Thermo Fisher Scientific alpha Synuclein Polyclonal Antibody
인간, 마우스, 랫트에서 알파 시뉴클레인 검출용 폴리클로날 항체. Western blot 및 동결 절편 면역조직화학에 적합. 합성 펩타이드 면역원으로 제작, 친화 크로마토그래피 정제. 장기 보관 시 -20°C에서 안정적.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–1.25 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | 3 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (AKEGVVAAAEKTKQGV, aa 11–27) identical in human alpha, beta, and gamma synuclein, conjugated to diphtheria toxoid |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1077524 |
Product Specific Information
PA1-18256 detects alpha, beta, and gamma Synuclein from human and rat samples.
Reconstitute with 100 µL of distilled water. After reconstitution, store aliquots at -20ºC for higher stability, and at 4ºC with an appropriate antibacterial agent.
Target Information
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Mutations in the SNCA gene, encoding alpha-synuclein, are linked to Parkinson’s disease. Alpha-synuclein peptides are also a major component of amyloid plaques in Alzheimer’s disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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