Thermo Fisher Scientific EBI3 Polyclonal Antibody
인간 EBI3 단백질에 특이적인 Rabbit Polyclonal Antibody로, WB 및 IHC 분석에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공. 면역반응 및 Th2 관련 연구에 적합한 연구용 시약.
- 카탈로그번호
- PA520662
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific EBI3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 2.5 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC-PFA) | 20 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide from near the carboxy terminus of human EBI3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 2–8°C for up to 3 months; long-term storage at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157051 |
Product Specific Information
- Suggested positive control: K562 cell lysate
- PA5-20662 can be used with blocking peptide PEP-0782
Target Information
EBI3 (Epstein-Barr virus Induced-3) is a secreted glycoprotein of the hematopoietin receptor family. It plays a critical regulatory role in Th2-type immune responses and Th2-mediated tissue inflammation. EBI3 dimerizes with IL-12 subunits p28 and p35 to form IL-27 and IL-35, respectively.
IL-27 is produced by activated antigen-presenting cells upon TLR ligation and negatively regulates Th17 cell differentiation. EBI3 expression in dendritic cells is controlled by TLR signaling via MyD88 and NF-κB. It suppresses IL-17 production while inducing IL-10 hyperproduction, thereby modulating delayed-type hypersensitivity responses.
EBI3 may also influence tumor metastasis through lung CD8+ T cells and is implicated in Th2 cytokine regulation related to allergic airway inflammation in asthma. Targeted deletion of EBI3 protects mice from lung metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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