Thermo Fisher Scientific RNAse H2A Polyclonal Antibody
Thermo Fisher Scientific의 RNAse H2A Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하는 토끼 유래 IgG 항체입니다. Western blot 및 Immunocytochemistry에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로 RNA/DNA 하이브리드 관련 연구에 적합합니다.
- 카탈로그번호
- PA520667
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide near the center of human RNAse H2A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155195 |
Product Specific Information
- Suggested positive control: HeLa cell lysate
- PA5-20667 can be used with blocking peptide PEP-0787
Target Information
Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. Their main role is to remove RNA strands from RNA/DNA hybrids formed during DNA replication and repair. RNAse H2 consists of three subunits, all essential for enzymatic activity.
Mutations in RNAse H2A or other subunits have been linked to Aicardi-Goutieres syndrome (AGS), a neurological disorder resembling viral brain infections with elevated IFN-alpha levels in cerebrospinal fluid. Similar phenotypes are seen with TREX1 mutations, suggesting that RNAse H2 and TREX1 share roles in preventing accumulation of intracellular nucleic acids that trigger innate immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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