Thermo Fisher Scientific GLE1 Polyclonal Antibody
GLE1 단백질 검출용 Rabbit Polyclonal Antibody로, WB와 IHC에 사용 가능. Human, Mouse, Rat에 반응하며 항원 친화 크로마토그래피로 정제됨. 1 mg/mL 농도의 액상 형태로 2-8°C에서 보관. mRNA 수출 연구에 적합한 연구용 시약.
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 2.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide near the center of human Gle1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Refrigerated at 2–8°C (up to 3 months); long-term at –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11151869 |
Product Specific Information
- Suggested positive control: 293 cell lysate
- PA5-20661 can be used with blocking peptide PEP-0781
Target Information
The proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and, in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a DEAD-box helicase family member, triggering mRNP remodeling and facilitating RNA export from the nucleus.
Mutations in Gle1 that cause defects in mRNA export have been linked to human disease. At least three isoforms of Gle1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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