Thermo Fisher Scientific Nicastrin Recombinant Rabbit Monoclonal Antibody (019)
Recombinant rabbit monoclonal antibody specific to human Nicastrin (NCSTN). Validated for WB, ICC/IF, and IP. Offers high specificity, lot-to-lot consistency, and preservative-free formulation. Suitable for research on gamma-secretase complex and Alzhe...
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Nicastrin Recombinant Rabbit Monoclonal Antibody (019)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | 0.2–1 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 019 |
| Immunogen | Recombinant Human Nicastrin/NCSTN protein (Met1–Glu669) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785300 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened for optimal production.
Advantages include:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to diverse rabbit immune repertoire
This antibody has specificity for human Nicastrin (NCSTN).
Target Information
NCSTN (Nicastrin) encodes a type I transmembrane glycoprotein, a component of the multimeric gamma-secretase complex. This complex cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein (APP).
The cleavage of APP produces amyloid beta peptide, the main component of neuritic plaques in Alzheimer’s disease. While NCSTN is implicated in Alzheimer’s pathology, its precise role remains uncertain. Mutations in NCSTN are also associated with familial acne inversa. A pseudogene is present on chromosome 21.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.