Thermo Fisher Scientific Nicastrin Recombinant Rabbit Monoclonal Antibody (004)
Recombinant rabbit monoclonal antibody recognizing human and mouse Nicastrin (NCSTN). Validated for WB and ICC/IF. Provides high specificity, lot-to-lot consistency, and preservative-free formulation. Suitable for research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:20–1:100 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 004 |
| Immunogen | Recombinant Human Nicastrin/NCSTN protein (Met1–Glu669) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785299 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
This antibody has specificity for human Nicastrin (NCSTN).
Target Information
NCSTN (Nicastrin) encodes a type I transmembrane glycoprotein that is a key component of the gamma-secretase complex. It participates in the cleavage of integral membrane proteins, including Notch receptors and beta-amyloid precursor protein (APP). The cleavage of APP produces amyloid beta peptide, a major component of neuritic plaques observed in Alzheimer’s disease. Although its precise role in Alzheimer’s disease remains unclear, mutations in NCSTN are associated with familial acne inversa. A pseudogene is located on chromosome 21.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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