Thermo Fisher Scientific CDH2 Monoclonal Antibody (UMAB23), UltraMAB
CDH2(N-cadherin) 단백질을 인식하는 UMAB23 단클론 항체로, Western blot, IHC, ICC, Flow cytometry에 적합합니다. 인간 시료에 반응하며, 액상 형태로 제공되고 PBS/BSA/glycerol 버퍼에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | – |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:150 | – |
| Immunocytochemistry (ICC/IF) | 1:100 | – |
| Flow Cytometry (Flow) | 1:100 | – |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB23 |
| Immunogen | Full length human recombinant protein of human CDH2 produced in HEK293T cells. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
N-cadherin is a 140 kDa transmembrane protein that mediates calcium-dependent intercellular adhesion. It plays a critical role in morphogenetic movements during development and regulates cell surface adhesion through homotypic interactions. The function of N-cadherin depends on its association with the actin cytoskeleton, mediated by interactions between its C-terminal region and cytoplasmic catenin proteins. This association is regulated by phosphorylation and dephosphorylation of beta-catenin. N-cadherin consists of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail, functioning during gastrulation and contributing to the establishment of left-right asymmetry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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