Thermo Fisher Scientific CDH2 Monoclonal Antibody (UMAB23), UltraMAB
인간 CDH2(N-cadherin)를 인식하는 Mouse IgG2a 단일클론 항체. WB, IHC, ICC/IF, Flow Cytometry에 적합. 무보존 Lyophilized 형태로 제공되며, 재구성 후 1 mg/mL 농도 유지. 연구용으로 세포 접착 및 형태발달 연구에 활용 가능.
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Thermo Fisher Scientific CDH2 Monoclonal Antibody (UMAB23), UltraMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB23 |
| Immunogen | Full length human recombinant protein of human CDH2 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
N-cadherin is a 140 kDa transmembrane protein mediating calcium-dependent intercellular adhesion. It plays a key role in morphogenetic movements during development and cell surface adhesion through homotypic interactions. Its function depends on association with the actin cytoskeleton and catenin proteins, regulated by phosphorylation of beta-catenin. N-cadherin consists of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail, essential for gastrulation and left-right asymmetry establishment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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