Thermo Fisher Scientific EDA2R Polyclonal Antibody
Human EDA2R 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제되었으며, PBS 및 글리세롤 완충액에 보관. 내인성 EDA2R 단백질 검출에 적합.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific EDA2R Polyclonal Antibody
Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to residues near the C-terminal of human ectodysplasin A2 receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.7 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635853 |
Product Specific Information
This antibody detects endogenous levels of total EDA2R protein.
Target Information
X-linked ectodysplasin-A2 receptor (XEDAR) is a member of the tumor necrosis factor receptor family, highly expressed during embryonic development and binds to ectodysplasin-A2 (EDA-A2).
Two main isoforms, XEDAR-s and XEDAR-L, differ by a 21-amino acid region near the cytoplasmic domain. Neither isoform possesses a death domain. Both act mainly through TRAF3 and TRAF6 to activate NF-kappa-B and JNK pathways.
Cells transfected with XEDAR and treated with EDA-A2 form a secondary complex containing FADD, caspase-8, and caspase-10, leading to activation of caspase-8 and caspase-3, and subsequently apoptosis. The EDA-A2-induced apoptosis depends on caspase-9 activation, as inhibitors of caspase-8 block apoptosis following EDA-A2 treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.