Thermo Fisher Scientific EID1 Polyclonal Antibody
EID1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. 인간 및 생쥐 시료에 반응하며 IHC(P) 적용 가능. 항원 친화 크로마토그래피로 정제, PBS/glycerol buffer에 보존. 연구용으로만 사용.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:25–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to residues near the N-terminal of human EP300 interacting inhibitor of differentiation 1 (EID1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2635854 |
Product Specific Information
The antibody detects endogenous levels of total EID1 protein.
Target Information
E1A-like inhibitor of differentiation-1 (EID-1) is an acetyltransferase enzyme that binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue-specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein.
EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. It also acetylates both histones and non-histone proteins such as the NCOA3 co-activator. By acetylating histones, EID-1 provides a specific tag for transcriptional activation.
In addition to binding Rb and p300, EID-1 also binds phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP-responsive genes as a co-activator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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