Thermo Fisher Scientific RNASE3 Polyclonal Antibody
RNASE3 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot과 IHC(파라핀 절편)에 사용 가능. 인간 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:25–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to a region derived from internal residues of human ribonuclease, RNase A family, 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635852 |
Product Specific Information
This antibody detects endogenous levels of total RNASE3 protein.
Target Information
ECP (eosinophil cationic protein), also known as RNS3 or RNASE3 (ribonuclease, RNase A family, 3), is a 160 amino acid potent cytotoxic secretory protein that belongs to the pancreatic ribonuclease family. ECP localizes to the granule matrix of the eosinophil and is involved in the immune response system. It acts as a cytotoxin, neurotoxin, and helminthotoxin secreted by activated human eosinophils. ECP exhibits anti-parasitic, antibacterial, and ribonucleolytic activities. It has been associated with the neurotoxic Gordon phenomenon, characterized by ataxia, muscular rigidity, paralysis, and tremor. ECP serves as a marker of eosinophilic inflammation, with elevated levels observed in active asthma and other allergic diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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