Thermo Fisher Scientific QSER1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human QSER1. Recombinant protein control fragment (Product #RP-88726).

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2646193

Product Specific Information

Immunogen sequence: QQHIETPGQN IPTKVTSAVV GPSHEVQEQS SGPFKKQSAT NLESEEDSEA PVDSTLNNNR NQEFVSSSRS ISGESATSES EFTLGGDDSG VSMNPARSAL ALLAMAQSGD AVSVKIEEEN QDLMHFNLQK KRAKGKGQVK

Highest antigen sequence identity to the following orthologs: Mouse - 66%, Rat - 66%.

Target Information

QSER1 (glutamine and serine-rich protein 1) is a 1,735 amino acid protein that is phosphorylated upon DNA damage, probably by Atm or ATR. A single nucleotide polymorphism (SNP) that is nearly equidistant between the genes QSER1 and PRRG4 on chromosome 11, at just under 20 kb from each, has been suspected of association with Parkinson disease. Existing as two alternatively spliced isoforms, the QSER1 gene is conserved in chimpanzee, canine, bovine, mouse, rat, chicken and zebrafish, and maps to human chromosome 11p13. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.