Thermo Fisher Scientific Phospho-Chk1 (Ser301) Polyclonal Antibody
Chk1 단백질의 Ser301 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC 등 다양한 응용 가능. 인간, 생쥐, 랫드에 반응하며, 1 mg/mL 농도의 액상 형태로 제공. DNA 손상 반응 연구 및 세포주기 조절 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CHEK1 (Accession O14757), corresponding to amino acid residues around phosphorylated Ser301 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816164 |
Product Specific Information
This antibody detects endogenous levels of Chk1 only when phosphorylated at Serine 301.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network and functions to ensure genomic integrity upon genotoxic stress. Inhibition of CHK1 can lead to mitotic catastrophe in p53-deficient cancer cells, making Chk1 an attractive therapeutic target for cancer treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-104691_Chk1_O14757-1_Rabbit.svg, PA5-104691_Chk1_O14757-1_Rabbit_PDP.jpeg)
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