Thermo Fisher Scientific Phospho-IKK beta (Tyr188) Polyclonal Antibody
IKK beta의 Tyr188 위치에서 인산화된 형태를 특이적으로 검출하는 폴리클로날 항체입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 사용 가능하며, 인간 및 설치류 등 여러 종에 반응합니다. 고순도 정제된 액상 형태로 제공되며, 연구용으로 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IKBKB (Accession O14920), corresponding to amino acid residues around phosphorylated Tyr188 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816166 |
Product Specific Information
This antibody detects endogenous levels of IKK beta only when phosphorylated at Tyrosine 188.
Target Information
Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex.
IKK beta (Inhibitor of nuclear factor kappa-B kinase subunit beta) is a serine kinase essential for NF-kappa-B signaling, activated by inflammatory cytokines, bacterial or viral products, DNA damage, and other cellular stresses.
It phosphorylates inhibitors of NF-kappa-B on critical serine residues, enabling polyubiquitination and proteasomal degradation. Consequently, NF-kappa-B translocates into the nucleus to activate transcription of genes involved in immune response, growth control, and apoptosis protection.
Mutations in the IKK beta gene can result in Immunodeficiency 15 (IMD15).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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