Thermo Fisher Scientific Phospho-IKK beta (Tyr199) Polyclonal Antibody

Thermo Fisher Scientific Phospho-IKK beta (Tyr199) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of IKK beta only when phosphorylated at Tyrosine 199.

Target Information

Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for degradation via the ubiquitination pathway, enabling activation of the NF-kappa-B complex.
IKK beta (Inhibitor of nuclear factor kappa-B kinase subunit beta) is a serine kinase essential for NF-kappa-B signaling, activated by various stimuli such as inflammatory cytokines, bacterial or viral products, DNA damage, or cellular stress.
IKK beta functions as part of the canonical IKK complex, phosphorylating inhibitors of NF-kappa-B on critical serine residues, leading to their polyubiquitination and proteasomal degradation.
This process allows NF-kappa-B to translocate into the nucleus and activate transcription of genes involved in immune response, growth control, and apoptosis protection.
Mutations in the IKK beta gene can result in Immunodeficiency 15 (IMD15).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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