Thermo Fisher Scientific Phospho-IKK beta (Tyr199) Polyclonal Antibody
IKK beta 단백질의 Tyr199 인산화 상태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. Human, Mouse, Rat 등 반응성 보유. 고순도 정제, -20°C 보관, 연구용 전용 시약.
- 카탈로그번호
- PA5104694
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-IKK beta (Tyr199) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human IKBKB (Accession O14920), corresponding to amino acid residues around phosphorylated Tyr199 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816167 |
Product Specific Information
This antibody detects endogenous levels of IKK beta only when phosphorylated at Tyrosine 199.
Target Information
Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for degradation via the ubiquitination pathway, enabling activation of the NF-kappa-B complex.
IKK beta (Inhibitor of nuclear factor kappa-B kinase subunit beta) is a serine kinase essential for NF-kappa-B signaling, activated by various stimuli such as inflammatory cytokines, bacterial or viral products, DNA damage, or cellular stress.
IKK beta functions as part of the canonical IKK complex, phosphorylating inhibitors of NF-kappa-B on critical serine residues, leading to their polyubiquitination and proteasomal degradation.
This process allows NF-kappa-B to translocate into the nucleus and activate transcription of genes involved in immune response, growth control, and apoptosis protection.
Mutations in the IKK beta gene can result in Immunodeficiency 15 (IMD15).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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