Thermo Fisher Scientific CD45 Monoclonal Antibody (ICO-59)
인간 CD45 단백질을 인식하는 마우스 단클론 항체로, ELISA 및 면역침전(IP)에 적합합니다. 단백질 A로 정제된 액상 포맷이며, 보존제 없이 PBS(pH 7.2)에 용해되어 있습니다. 단기 4°C, 장기 -80°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| ELISA | 1:1,000 | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ICO-59 |
| Immunogen | Leukocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2 |
| Contains | No preservative |
| Storage Conditions | 4°C (short term), -80°C (long term) |
| RRID | AB_1072391 |
Product Specific Information
MA1-7654 detects CD45 from human samples.
It has been successfully used in Immunoprecipitation and ELISA procedures.
The immunogen used for MA1-7654 is leukocytes.
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed in all nucleated hematopoietic cells, comprising about 10% of all surface proteins in lymphocytes.
It is absent in non-hematopoietic cell lines and tissues.
CD45 plays a key role in lymphocyte development and antigen signaling, regulating Src-family kinases and JAK kinases, and influencing cytokine receptor signaling.
Different CD45 isoforms arise from alternative splicing and vary in extracellular domains, expression patterns, and signaling roles.
It is also involved in cell survival, apoptosis regulation, and modulation of integrin-mediated signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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