Thermo Fisher Scientific CD45 Monoclonal Antibody (ICO-166)
인간 CD45 단백질을 인식하는 마우스 단클론 항체. ELISA 및 면역침전(IP)에 사용 가능. B-, T-, NK-세포 유래 면역원으로 제작. Protein A로 정제된 액상 형태, 1 mg/mL 농도. 단기 4°C, 장기 -80°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| ELISA | 1:1,000 | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ICO-166 |
| Immunogen | B-cells, T-cells, NK-cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2 |
| Contains | No preservative |
| Storage Conditions | 4°C (short term), -80°C (long term) |
| RRID | AB_1072390 |
Product Specific Information
- MA1-7655 detects CD45 from human samples.
- Suitable for use in Immunoprecipitation and ELISA.
- Immunogen: B-cells, T-cells, NK-cells.
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed in all nucleated hematopoietic cells, comprising about 10% of lymphocyte surface proteins.
It is absent in non-hematopoietic tissues and cell lines. CD45 plays a crucial role in lymphocyte development and antigen signaling, regulating Src-family kinases.
Multiple isoforms exist due to alternative splicing, sharing identical transmembrane and cytoplasmic domains but differing in extracellular regions.
CD45RA is one isoform with restricted expression among lymphoid cell subtypes.
CD45 regulates T- and B-cell receptor signaling, suppresses JAK kinases, and modulates integrin-mediated signal transduction, apoptosis, and other immune functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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