Thermo Fisher Scientific CD38 Monoclonal Antibody (ICO-20)

Applications

ELISA (ELISA)

• Tested Dilution: 1:1,000

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• MA1-7653 detects CD38 from human samples.
• Suitable for use in ELISA and Immunoprecipitation.
• Immunogen: Hematopoietic precursors, thymocytes, activated T-cells, and plasma cells.
• Storage: 4ºC (short term), -80ºC (long term).

Target Information

CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes, and mediates apoptosis of myeloid and lymphoid progenitor cells.
It functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD⁺ glycohydrolase, or as a cell surface receptor.

Antibodies to CD38 are useful in:

• Subtyping of lymphomas and leukemias
• Detection of plasma cells (e.g., myeloma identification)
• Marker for activated B and T cells

CD38 participates in cell adhesion, signal transduction, and calcium signaling. It is highly expressed in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.