Thermo Fisher Scientific TCR V beta 10b Monoclonal Antibody (B21.5), Biotin, eBioscience
마우스 TCR Vβ10b를 인식하는 단클론 항체로, Flow Cytometry 분석에 적합합니다. Biotin으로 표지되어 있으며 Rat IgG2a, λ 아이소타입을 가집니다. 0.5 mg/mL 농도의 액상 형태로 제공되며, 4°C 암소 보관 권장됩니다.
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TCR V beta 10b Monoclonal Antibody (B21.5), Biotin, eBioscience
Thermo Fisher Scientific TCR V beta 10b Monoclonal Antibody (B21.5), Biotin, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution: 0.25 µg/test
Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a, λ |
| Recommended Isotype Control | Rat IgG2a κ Isotype Control (eBR2a), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | B21.5 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10698309 |
| Filtration | 0.2 µm post-manufacturing filtered |
Additional Formats
Product Specific Information
The B21.5 monoclonal antibody reacts with the Vβ10 T Cell Receptor (TCR) in mice of the b haplotype of the TCR Vβ gene complex, including AKR, BALB/c, CBA, C3H/He, C57BL, DBA/1, and DBA/2 mice.
It does not react with Vβ10 in mice of the a or c haplotypes, including C57BR, C57L, SJL, and SWR mice.
Applications Reported:
This B21.5 antibody has been reported for use in flow cytometric analysis.
Applications Tested:
Tested by flow cytometric analysis of C57Bl/6 mouse splenocytes.
Recommended use ≤ 0.25 µg per test (100 µL final volume).
Cell number should be determined empirically (10⁵–10⁸ cells/test).
Careful titration is recommended for optimal performance.
Target Information
T cell receptors (TCRs) discriminate foreign from self-peptides presented by MHC class II molecules, which is critical for adaptive immune response.
Recognition of self-peptides has been linked to autoimmune diseases, and mutant self-peptides are associated with tumors.
Superantigens engaging TCRs can cause toxic shock syndrome.
Autoantibodies to Vβ segments have been found in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), potentially blocking TH1-mediated inflammatory responses.
T Cell and TCR Diversity:
Most human T cells express TCR αβ and either CD4 or CD8 (single positive).
A small subset lacks both markers (double negative, DN), which may increase in autoimmune or immunodeficiency disorders.
γδ T cells, mainly in epithelial tissues, show less TCR diversity and exhibit antitumor and immunoregulatory activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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