Thermo Fisher Scientific CD45 Monoclonal Antibody (YKIX716.13), APC
Thermo Fisher Scientific의 CD45 단클론 항체(YKIX716.13)는 개(Canine) CD45 인식용 Rat IgG2b 형 항체로, APC 형광체로 결합되어 있습니다. 유세포분석(Flow Cytometry)에 적합하며, 단백질 G로 정제된 동결건조 형태로 제공됩니다. 4°C 암소 보관.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: Neat
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | YKIX716.13 |
| Immunogen | Canine thymocytes |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Protein G |
| Storage Buffer | PBS with 1% BSA, 5% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538467 |
Additional Formats
- Unconjugated (MA5-28387)
- Biotin (MA5-16996)
- FITC (MA1-80304)
- PE (MA1-81225)
- Request custom conjugation
Product Specific Information
Reconstitute with 1 mL of distilled water. After reconstitution, store undiluted at 4°C in the dark.
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.
Rat anti-Dog CD45 antibody, clone YKIX716.13 recognizes canine CD45, also known as leukocyte common antigen, clustered as Canine CD45 in the First Canine Leukocyte Antigen Workshop (CLAW).
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed in all nucleated hematopoietic cells, comprising about 10% of all surface proteins in lymphocytes. It is absent on non-hematopoietic cells and tissues.
CD45 glycoprotein plays a crucial role in lymphocyte development and antigen signaling, regulating Src-family kinases. Multiple isoforms exist due to alternative splicing, differing in extracellular domains but sharing identical transmembrane and cytoplasmic domains.
CD45RA is an isoform with restricted expression among lymphoid cell subtypes. CD45 regulates T- and B-cell antigen receptor signaling, suppresses JAK kinases, and modulates cytokine receptor signaling. It also promotes cell survival and affects integrin-mediated signaling, apoptosis, and immunological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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