Thermo Fisher Scientific CD45 Monoclonal Antibody (YKIX716.13), Biotin

Thermo Fisher Scientific CD45 Monoclonal Antibody (YKIX716.13), Biotin

Applications

• Flow Cytometry (Flow)

Tested Dilution: Neat
Publications: -

Product Specifications

Additional Formats

• Unconjugated
• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.

Target Information

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. It is absent on non-hematopoietic cells and tissues. CD45 plays a crucial role in lymphocyte development and antigen signaling, regulating Src-family kinases and JAK kinases. It promotes cell survival by modulating integrin-mediated signaling, apoptosis, and various immune functions. CD45 exists in multiple isoforms due to alternative splicing, differing in extracellular domains but sharing identical transmembrane and cytoplasmic regions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.