Thermo Fisher Scientific STING1/TMEM173 Monoclonal Antibody (STING1/7436)
STING1/TMEM173 단백질을 인식하는 Mouse Monoclonal Antibody로, Western Blot 및 Immunohistochemistry에 적합. 인간 시료에 반응하며 Protein A/G로 정제된 액상형 항체. STING 관련 선천면역 신호 연구에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | STING1/7436 |
| Immunogen | Recombinant fragment (around aa190–290) of human TMEM173 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
STING is a 379-amino-acid signaling protein that plays a key role in innate immune signaling. It activates NF-kappa-B and IRF3 transcription pathways, inducing type I interferon (IFN-alpha and IFN-beta) expression and establishing an antiviral state. STING may also have translocon functions, influencing interferon induction and apoptotic signal transduction via MHC-II association. It facilitates detection of intracellular viral RNA and B-form DNA and mediates death signaling through ERK pathway activation. STING is generally localized in the endoplasmic reticulum membrane, cell membrane, and mitochondrial outer membrane, and is ubiquitously expressed in most tissues.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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