Thermo Fisher Scientific STING1/TMEM173 Monoclonal Antibody (STING1/7436)
STING1/TMEM173 단백질을 인식하는 마우스 단클론 항체로, WB 및 IHC(P, PFA) 실험에 적합합니다. NF-κB 및 IRF3 경로를 통한 선천 면역 신호 연구에 활용되며, 고순도 Protein A/G 정제 및 4°C 보관 조건을 갖습니다.
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Thermo Fisher Scientific STING1/TMEM173 Monoclonal Antibody (STING1/7436)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | STING1/7436 |
| Immunogen | Recombinant fragment (around aa190–290) of human TMEM173 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
STING is a 379-amino-acid signaling protein that plays a crucial role in innate immune signaling. It activates NF-κB and IRF3 transcription pathways to induce expression of type I interferons (IFN-α and IFN-β), promoting antiviral responses.
STING may function as a translocon influencing interferon induction and is involved in apoptotic signal transduction through association with MHC-II. It mediates detection of intracellular viral RNA and B-form DNA, and triggers death signaling via ERK pathway activation.
Predominantly localized in the endoplasmic reticulum membrane, cell membrane, and outer mitochondrial membrane, STING is expressed ubiquitously across most tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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