Thermo Fisher Scientific Phospho-MYPT1 (Ser299) Polyclonal Antibody
MYPT1 단백질의 Ser299 인산화 상태를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot 및 IHC(P)에서 검증됨. Human, Mouse, Rat 반응성. PBS/glycerol buffer에 보관되며 -20°C에서 안정적. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PPP1R12A (Accession O14974), corresponding to amino acid residues around phosphorylated Ser299 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816806 |
Product Specific Information
This antibody detects endogenous levels of MYPT1 only when phosphorylated at Ser299.
Target Information
Myosin phosphatase target subunit 1 (MYPT1), also known as the myosin-binding subunit of myosin phosphatase, is a regulatory component of the myosin phosphatase complex. It modulates the interaction between actin and myosin downstream of the Rho GTPase signaling pathway. Activated RhoA (GTP-bound form) interacts with MYPT1, influencing the phosphorylation state of myosin light chain (MLC) and thus regulating smooth muscle contraction and cytoskeletal dynamics in nonmuscle cells. Rho-associated kinase (Rho-kinase) phosphorylates MYPT1, leading to inhibition of myosin phosphatase activity. Multiple transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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