Thermo Fisher Scientific Phospho-PDCD5 (Ser119) Polyclonal Antibody
PDCD5 단백질의 Ser119 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 인간·마우스·랫트 시료에 반응합니다. 고순도 정제 및 안정적 PBS/glycerol 버퍼로 제공됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PDCD5 (Accession O14737), corresponding to amino acid residues around phosphorylated Ser119 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816804 |
Product Specific Information
This antibody detects endogenous levels of PDCD5 only when phosphorylated at Ser119.
Target Information
Programmed cell death 5 (PDCD5) is an apoptosis-related protein that plays an early and universal role in apoptotic processes. PDCD5 is widely expressed and upregulated during apoptosis, rapidly translocating from the cytoplasm to the nucleus. It has a compact core structure with two mobile N-terminal alpha-helices and a flexible C-terminal region. Charged residues are crucial for apoptosis promotion and protein translocation. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. It may function as a Tip60 co-activator to promote apoptosis, and nucleotide polymorphisms in its promoter region are associated with leukemia and lung cancer susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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