Thermo Fisher Scientific Aminoacylase Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Immunogen sequence:
MTSKGPEEEH PSVTLFRQYL RIRTVQPKPD YGAAVAFFEE TARQLGLGCQ KVEVAPGYVV TVLTWPGTNP TLSSILLNSH TDVVPVFKEH WSHDPFEAFK DSEGYIYARG AQDMKCVSIQ YLEAVRRLKV EGHRFPRTIH MTFVPDEEVG GHQGMELFVQ RPEFHALRAG FALDEGIANP TDAFTVFYSE RSPWWVRVTS TGRPGHASRF MEDTAAEKLH KVVNSILAFR EKEWQRLQSN PHLKEGSVTS VNLTKLEGGV AYNVIPATMS ASFDFRVAPD VDFKAFEEQL QSWCQAAGEG VTLEFAQKWM HPQVTPTDDS NPWWAAFSRV CKDMNLTLEP EIMPAATDNR YIRAVGVPAL GFSPMNRTPV LLHDHDERLH EAVFLRGVDI YTRLLPALAS VPALPSDS

Positive Samples: HepG2, U-251MG, A-431, Mouse kidney, Rat kidney
Cellular Location: Cytoplasm

Target Information

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It is involved in the catabolism and salvage of acylated amino acids. The gene is located on chromosome 3p21.1, a region associated with small-cell lung cancer (SCLC), where its expression is often reduced or undetectable.
The human aminoacylase-1 sequence is highly homologous to the porcine counterpart and represents the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by CNS defects and increased urinary excretion of N-acetylated amino acids.
Alternative splicing results in multiple transcript variants, and read-through transcription occurs with the upstream ABHD14A gene. A related pseudogene exists on chromosome 18.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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