Thermo Fisher Scientific TBLR1 Polyclonal Antibody
TBLR1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, ICC/IF, ELISA에 사용 가능. 인간 및 마우스 반응성. 고순도 Affinity Chromatography 정제, PBS/glycerol buffer에 보관. 핵 내 TBLR1 단백질 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 120–170 of human TBL1XR1 (NP_0789412) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.15 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805436 |
Product Specific Information
- Immunogen sequence: QQGSAKNGEN TANGEENGAH TIANNHTDMM EVDGDVEIPP NKAVVLRGHE S
- Positive Samples: Jurkat, HepG2, NCI-H460, THP-1, Mouse brain, Mouse spleen, Mouse thymus
- Cellular Location: Nucleus
Target Information
Chromatin organization plays a fundamental role in regulating transcription in eukaryotic cells. The nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid hormone receptors (SMRT) are involved in diverse transcriptional repression pathways. These complexes mediate repression partly by recruiting histone deacetylases (HDACs) to form repressive chromatin. HDAC3 is the main HDAC associated with N-CoR and SMRT complexes, essential for repression. TBLR1, a WD-40 repeat protein, also associates with these complexes and is considered a core component, though its precise role remains to be elucidated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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