Thermo Fisher Scientific ERN1 Monoclonal Antibody (1F12)
Thermo Fisher Scientific의 ERN1 Monoclonal Antibody (1F12)은 인간 ERN1 단백질을 인식하는 Mouse IgG2a 형 단일클론 항체로, Western blot 및 ELISA에 적합합니다. GST 태그가 포함된 재조합 단백질로 면역화되었으며, PBS buffer에 보존되어 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.1 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1F12 |
| Immunogen | ERN1 (AAC25991, 401–500 a.a.) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
EEVINLVDQT SENAPTTVSR DVEEKPAHAP ARPEAPVDSM LKDMATIILS TFLLIGWVAF IITYPLSMHQ QQQLQHQQFQ KELEKIQLLQ QQQQQLPFHP
Target Information
ERN1 serine/threonine kinase, also known as endoplasmic reticulum to nucleus signaling 1, is a human homologue of the yeast Ire1 gene product. It possesses intrinsic kinase and endoribonuclease activities, playing a crucial role in ER-based stress signaling.
ERN1 controls IRE1 proteolysis in mammalian cells and is essential for fetal viability. Specifically, IRE1 acts as a sensor of unfolded proteins in the ER and initiates the unfolded protein response by splicing XBP1 mRNA, converting it into a potent transcriptional activator.
Null mutants are viable but IRE1 is essential under stress conditions that cause unfolded protein accumulation in the ER. Depletion of IRE1p via dominant negative expression leads to apoptosis under such stress conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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