Thermo Fisher Scientific ERN1 Monoclonal Antibody (3D1)
Thermo Fisher Scientific의 ERN1 Monoclonal Antibody (3D1)은 인간 ERN1 단백질을 인식하는 mouse IgG1 항체로, Western blot, IHC, ELISA에 적합합니다. GST 태그된 ERN1 부분 재조합 단백질로 면역화되었으며, 액상 형태로 -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1.5 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3D1 |
| Immunogen | ERN1 (AAC25991, 401 a.a. approximately 500 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 KDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
EEVINLVDQT SENAPTTVSR DVEEKPAHAP ARPEAPVDSM LKDMATIILS TFLLIGWVAF IITYPLSMHQ QQQLQHQQFQ KELEKIQLLQ QQQQQLPFHP
Target Information
ERN1 (endoplasmic reticulum to nucleus signaling 1) is a serine/threonine kinase that acts as a sensor of unfolded proteins in the ER. It transmits the unfolded protein signal from the ER to the nucleus by splicing XBP1 mRNA, converting it into a potent transcriptional activator. ERN1 regulates IRE1 proteolysis and plays a crucial role in extraembryonic cell viability and stress response. Null mutants are viable under normal conditions but not under ER stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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