Thermo Fisher Scientific ERN1 Monoclonal Antibody (8D12)
Thermo Fisher Scientific의 ERN1 Monoclonal Antibody (8D12)은 인간 ERN1 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, Western blot, ICC/IF, ELISA, PLA 등 다양한 응용에 적합합니다. 액상 형태로 제공되며, PBS(pH 7.4)에 보존제 없이 저장됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 25 µg/mL |
| ELISA | 0.03 ng/mL |
| in situ PLA (PLA) | 1:1200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8D12 |
| Immunogen | ERN1 (AAC25991, 401 a.a. ~500 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
EEVINLVDQT SENAPTTVSR DVEEKPAHAP ARPEAPVDSM LKDMATIILS TFLLIGWVAF IITYPLSMHQ QQQLQHQQFQ KELEKIQLLQ QQQQQLPFHP
Target Information
ERN1 serine/threonine kinase (also known as endoplasmic reticulum to nucleus signaling 1) is a human homologue of the yeast Ire1 gene product. It possesses intrinsic kinase and endoribonuclease activities and plays a key role in ER-based stress signaling. ERN1 controls IRE1 proteolysis in mammalian cells and is essential for fetal viability.
IRE1 acts as a sensor of unfolded proteins in the ER, initiating the unfolded protein response (UPR) by splicing XBP1 mRNA into an active transcriptional activator form. Null mutants remain viable under normal conditions but are sensitive to ER stress. Under stress conditions that cause unfolded protein accumulation, depletion of IRE1p leads to apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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