Thermo Fisher Scientific PTPN2 Polyclonal Antibody
Human 및 Rat 반응성을 가진 Rabbit Polyclonal 항체로 TCPTP 단백질을 인식. Western blot, IHC, ICC/IF 실험에 적합하며 항원 친화 크로마토그래피로 정제됨. Lyophilized 형태로 제공되며 재구성 후 500 µg/mL 농도 유지. 연구용 전용 제품.
- 카탈로그번호
- PA579895
- 판매단위
- pk
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Thermo Fisher Scientific PTPN2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E.coli-derived human TCPTP recombinant protein (Position: M1–C330) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2747010 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. This enzyme exists in two C-terminal splice variants with distinct subcellular localizations:
- 45 kDa isoform: Exclusively nuclear in resting cells, redistributes to the cytosol upon stimulation with growth factors and cellular stress.
- 48 kDa isoform: Found in the endoplasmic reticulum and has different physiological substrates.
TC-PTP is prominent in hemopoietic cell types. Knockout mice lacking TC-PTP die 3–5 weeks after birth due to erythropoietic and lymphopoietic deficits, indicating its critical role in bone marrow maturation. It dephosphorylates various phosphoproteins, including p52 Shc and receptors for EGF, Insulin, and growth hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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