Thermo Fisher Scientific PNR Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

2 µg/mL

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues R(392) K T I G N T P M E K L L C D M F K N(410) of human PNR. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PNR,uniProtId:Q9Y5X4-1,ncbiNodeId:9606,antigenRange:393-410,antigenLength:410,antigenImageFileName:PA1-809_PNR_Q9Y5X4-1_Rabbit.svg,antigenImageFileNamePDP:PA1-809_PNR_Q9Y5X4-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2155474

Product Specific Information

PA1-809 detects PNR from rat and human samples.

PA1-809 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~42 kDa protein representing PNR from rat tissue extracts.

The PA1-809 immunogen is a synthetic peptide corresponding to residues R(392) K T I G N T P M E K L L C D M F K N(410) of human PNR. This sequence is completely conserved between mouse and chicken. This immunizing peptide (cat. # PEP-237) can be used for neutralization and control experiments.

Target Information

NR2E3, a NR2 Hepatocyte NF4-Like Receptor, has been suggested to affect cone cell proliferation in eye development. It has been shown to have a role in determining photoreceptor phenotype during human retinogenesis. In RD7 mice, a deletion in NR2E3 results in hereditary retinal dysplasia and degeneration. A homozygous missense mutation in NR2E3 has been linked to retinitis pigmentosa in Crypto-Jews of Belmonte. Two alternatively spliced isoforms have been documented. NR2E3 is expressed in the retina. ESTs have been isolated from cancerous human lung, colon, and ovary, and from normal human eye.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.