Thermo Fisher Scientific TPH1 Polyclonal Antibody
TPH1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, IP 등 다양한 응용 가능. 인간, 마우스, 랫, 토끼 및 비인간 영장류 시료에서 반응. 합성 펩타이드 면역원 기반, 1 mg/mL 농도, PBS buffer에 보관.
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Thermo Fisher Scientific TPH1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:1,000 | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:10–1:500 | View 1 publication |
| Immunoprecipitation (IP) | 1:1,000 | View publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rabbit, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminal region of TPH1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2256401 |
Product Specific Information
PA1-777 detects TPH1 in human, mouse, rat, rabbit, and non-human primate samples.
It has been successfully used in ICC/IF, IP, and Western blot procedures.
By Western blot, PA1-777 detects a 51 kDa protein representing TPH1.
The immunogen is a synthetic peptide corresponding to the C-terminal region of TPH1.
Target Information
Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, the first step in the biosynthesis of indoleamines (serotonin and melatonin).
In mammals, serotonin biosynthesis occurs predominantly in neurons originating in the Raphe nuclei of the brain, while melatonin synthesis takes place within the pineal gland.
TPH activity is rate-limiting for serotonin but not melatonin biosynthesis.
Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland.
TPH activity is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca²⁺/calmodulin kinase II (CAM K II).
Both PKA and CAM K II phosphorylate Ser58 within the regulatory domain of TPH.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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(이미지 파일명: PA1-777_TPH1_P17752-1_Rabbit.svg, PA1-777_TPH1_P17752-1_Rabbit_PDP.jpeg)
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