Thermo Fisher Scientific FOXP3 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

PA1-806 detects FOXP3 from human samples.
PA1-806 has been successfully used in Western blot and ChIP procedures.
By Western blot, PA1-806 detects a ~50 kDa band representing FOXP3 from HeLa cells.
The PA1-806 immunogen is a synthetic peptide corresponding to residues W(406) T V D E L E F R K K R S Q R(420) of human FOXP3.
PA1-806 can be used with blocking peptide PEP-297.

Target Information

FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis.
FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25+ CD4+ regulatory T cells, a low level in CD4+/CD25− cells, and is absent in CD4−/CD8+ T cells.
FOXP3 may be a master regulatory gene and a specific marker of regulatory T cells.
Defects in FOXP3 cause the scurfy phenotype in mice and play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome) in humans.
FOXP3 expression is regulated by p53 in response to DNA damage in human breast and colon cancer cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.