Thermo Fisher Scientific RARA Polyclonal Antibody
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
PA1810A | - | Thermo Fisher Scientific PA1810A RARA Polyclonal Antibody 100 ul pk | 재고문의 | pk | 654,000원 | - | 719,400원 |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
Western Blot (WB)
1:1,000
View 1 publication 1 publication
Immunocytochemistry (ICC/IF)
1:250
Product Specifications
Species Reactivity
Human, Mouse
Published species
Mouse
Host/Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues C S(444) P S L S P S S H R S S P A T Q S P (462) of mouse RAR alpha. if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
RARA,
uniProtId:
P11416-1,
ncbiNodeId:
10090,
antigenRange:
445-462,
antigenLength:
462,
antigenImageFileName:
PA1-810A_RARA_P11416-1_Rabbit.svg,
antigenImageFileNamePDP:
PA1-810A_RARA_P11416-1_Rabbit_PDP.jpeg,
sortOrder:
2}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum, PBS
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2177730
Product Specific Information
PA1-810A detects retinoic acid receptor (RAR) from human and mouse tissues and cells. This antibody does not detect RAR beta or gamma forms.
PA1-810A has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~50-58 kDa protein representing RAR alpha from Jurkat, CEM-C7, and IM9 cells.
The PA1-810A immunogen is a synthetic peptide corresponding to residues C S(444) P S L S P S S H R S S P A T Q S P (462) of mouse RAR alpha. PA1-810A immunizing peptide (Cat. # PEP-004) is available for use in neutralization and control experiments.
Target Information
RARA is a receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5-AGGTCA-3
sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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