Thermo Fisher Scientific VDR Polyclonal Antibody
Goat 유래의 VDR Polyclonal Antibody로 Western blot 및 ELISA에 사용 가능. 인간 VDR 단백질을 인식하며, 개·마우스·랫에서도 반응 예상. 액상 형태로 제공되며 4°C 단기 보관, -20°C 장기 보관 권장. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.3–1 µg/mL |
| ELISA | 1:16,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide CGNQDYKYRVSD corresponding to the internal region of VDR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2288246 |
Product Specific Information
- Predicted to react with dog, mouse, and rat based on sequence homology.
- In Western blot, this antibody detects a band at ~40–45 kDa in human brain cell lysate.
- A minimum incubation time of 1 hour is recommended.
- Goat anti-Human Vitamin D Receptor antibody recognizes human vitamin D nuclear hormone receptor (VDR), an approximately 48 kDa member of the trans-acting transcriptional regulatory factors.
Target Information
Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to DNA sequences following activation by appropriate hormones.
The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the superfamily of steroid hormone receptors, including estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors.
Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation.
VDR is found in the intestine, bone, kidney, epidermis, and cells of the endocrine immune system.
Repression of T-cell proliferation and interleukin-2 (IL-2) gene expression occurs when VDR binds within the IL-2 enhancer.
Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)₂D₃ interferes with assembly of NFATp/Fos/Jun/DNA complex and subsequent IL-2 gene transcription.
The corresponding gene for the vitamin D receptor is NR1I1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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