Thermo Fisher Scientific Syk Polyclonal Antibody
Human Syk 단백질을 인식하는 Goat Polyclonal Antibody로 Western blot 및 ELISA에 적합. 내부 서열(aa 458–470)에서 유래한 펩타이드로 면역화됨. Affinity chromatography로 정제된 액상 항체이며, 0.5 mg/mL 농도. 단기 4°C, 장기 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| ELISA | 1:16,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-KYLQQNRHVKDKN from the internal region of the SYK sequence (aa 458–470) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2271206 |
Product Specific Information
- Predicted to react with dog, mouse, and rat based on sequence homology.
- In Western blot, detects a band at approximately 70 kDa in human bone marrow, lymph node, and spleen lysates.
- Goat anti-Syk antibody recognizes an epitope within the internal region of SYK, a ~70 kDa non-receptor protein tyrosine kinase involved in signaling pathways in hematopoietic and non-hematopoietic stem cells.
Target Information
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases considered potential drug targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer.
Upon B cell antigen receptor (BCR) or high-affinity IgE receptor (FcεRI) activation, Syk translocates to the plasma membrane and phosphorylates downstream adaptor proteins, initiating signaling pathways such as calcium mobilization, cytoskeleton remodeling, and gene transcription.
Syk binds receptor assemblies through its SH2 domains with ITAM motifs phosphorylated by Src-family kinases, which also activate Syk via phosphorylation of its activation loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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