Thermo Fisher Scientific STAT3 Polyclonal Antibody

Thermo Fisher Scientific STAT3 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Predicted to react with rat based on sequence homology.
• Overnight staining is recommended for this antibody.
• Goat anti-Mouse STAT3 antibody recognizes an epitope within the C-terminal region of STAT3 (80–85 kDa), a key member of the STAT protein family involved in cell growth, survival, differentiation, and transformation.
• STAT3 transduces signals from cytokine receptors to the nucleus.

Target Information

STAT3 belongs to the family of signal transducers and activators of transcription (STAT) proteins. These proteins are phosphorylated by receptor-associated kinases, translocate to the nucleus, and act as transcription factors in response to cytokines and growth factors. Coactivators such as CREB-binding protein are required for transcriptional activation by STAT3.

STAT3 can be activated by Interferon-alpha, Interferon-gamma, EGF, PDGF, and IL6. Phosphorylation on tyrosine 705 by JAK1 and JAK2 is essential for STAT3 dimer formation, nuclear translocation, and DNA binding activity. In humans, the STAT3 gene is located on chromosome 17q.

STAT3 mediates the expression of various genes in response to cellular stimuli, playing a key role in processes such as cell growth and apoptosis. Rac1 binds and regulates STAT3 activity, while PIAS3 acts as a specific inhibitor. Three alternatively spliced transcript variants encoding distinct isoforms of STAT3 have been described. Deletion of the STAT3 gene in knockout mice is lethal at the early embryonic stage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.