Thermo Fisher Scientific PHAP Polyclonal Antibody
PHAP 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot과 IHC에 사용 가능. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체이며, 1 mg/mL 농도. 세포사멸 관련 연구에 적합.
- 카탈로그번호
- PA520026
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids at carboxy terminus of human PHAP I. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153598 |
Product Specific Information
- In Western blot applications, this antibody detects bands at approximately 32 kDa and 35 kDa.
- A suggested positive control is Raji cell lysate.
- PA5-20026 can be used with blocking peptide PEP-0145.
Target Information
Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after release from mitochondria, binds to Apaf-1 to form an apoptosome, which activates procaspase-9. Activated caspase-9 cleaves and activates effector caspases (caspase-3, -6, and -7), responsible for proteolytic cleavage of key proteins in apoptosis.
The tumor suppressor putative HLA-DR-associated proteins (PHAPs) have been identified as important regulators of mitochondrial apoptosis. PHAP facilitates apoptosome-mediated caspase-9 activation and stimulates the mitochondrial apoptotic pathway. It also opposes Ras- and Myc-mediated cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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