Thermo Fisher Scientific TIRAP Polyclonal Antibody

Thermo Fisher Scientific TIRAP Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• A suggested positive control is human heart tissue lysate.
• PA5-20028 can be used with blocking peptide PEP-0147.

Target Information

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors.
In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are resistant to the toxic effects of LPS and show defects in NF-βB and MAP kinase activation, indicating that TIRAP is also involved in TLR4 signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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