Thermo Fisher Scientific Phospho-Androgen Receptor (Ser310) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of Androgen Receptor only when phosphorylated at Ser310.

Target Information

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, the receptor translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes.

AR signaling is crucial for male reproductive organ development (e.g., prostate, epididymis) and also functions in nonreproductive tissues such as muscle, hair follicles, and brain. AR is a phosphoprotein that regulates MAP kinase pathways, and its phosphorylation state correlates with MEK1/2 pathway inhibition. Abnormal AR signaling is associated with diseases such as prostate cancer, Kennedy’s disease, and male infertility. Mutations in the AR gene can cause complete androgen insensitivity syndrome (CAIS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.