Thermo Fisher Scientific CXCR5 Polyclonal Antibody

Applications

Tested Application

• Immunohistochemistry (Paraffin) (IHC (P)): 5–18 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey (100%)
Mouse, Rat, Dog, Bovine, Hamster, Panda, Rabbit, Pig (94%)

Target Information

CXCR5 (C-X-C Chemokine Receptor Type 5, CD185), also known as Burkitt lymphoma receptor 1 (BLR1), belongs to the CXC chemokine receptor family.
CXCR5 is a G protein-coupled seven transmembrane receptor for chemokine BLC and is specifically expressed in Burkitt’s lymphoma and lymphatic tissues such as lymph node follicles and spleen.
Studies indicate CXCR5 plays an essential role in B cell migration.
CXCR5 expression has been reported in human blood and salivary gland, and in various animal tissues including lymphatic organs, blood, bone marrow, brain, liver, lymph node, skin, spleen, stomach, and tonsil.
ESTs have been isolated from human brain, germ cell, lung, lymph, and pancreas.

G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules, sharing a structural motif of seven membrane-spanning helices and existing in active and inactive forms.
GPCRs are involved in complex signaling and regulatory mechanisms, making them key targets in pharmacological research.
Examples of GPCR-targeted pharmaceuticals include Zyprexa (Eli Lilly) and Claritin (Schering-Plough), used in mental health and allergy treatments, respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.