Thermo Fisher Scientific CXCR5 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 5 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Gorilla (100%); Monkey, Hamster (94%); Gibbon, Mouse, Rat, Dog, Bovine, Panda, Pig (89%).

Target Information

CXCR5 (C-X-Chemokine Receptor Type 5, CD185), also known as Burkitt lymphoma receptor 1 (BLR1), belongs to the CXC chemokine receptor family.
CXCR5 is a G protein-coupled seven transmembrane receptor for chemokine BLC. The CXCR5 gene is specifically expressed in Burkitt’s lymphoma and lymphatic tissues such as lymph node follicles and spleen.

Studies suggest CXCR5 plays an essential role in B cell migration. CXCR5 expression has been reported in human blood and salivary gland and in animal lymphatic organs, blood, bone marrow, brain, liver, lymph node, skin, spleen, stomach, and tonsil.
ESTs have been isolated from human brain, germ cell, lung, lymph, and pancreas.

G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules. All GPCRs share a structural motif of seven membrane-spanning helices and exist in both active and inactive forms. Activating ligands induce conformational changes leading to signaling via G-proteins and downstream effectors.
Research has also shown mechanisms for negative regulation of GPCRs, which are important for cellular physiological actions and pharmacological research. GPCR-targeted drugs include Zyprexa (Eli Lilly) and Claritin (Schering-Plough), used in mental health and allergy treatments.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

제품 이미지

(이미지 파일: PA5-33459_CXCR5_P32302-1_Rabbit.svg, PA5-33459_CXCR5_P32302-1_Rabbit_PDP.jpeg)