Thermo Fisher Scientific SLP76 Polyclonal Antibody
SLP76 단백질을 인식하는 Rabbit Polyclonal Antibody로, 인간 및 마우스 시료에 반응합니다. WB, IHC, ICC/IF 등 다양한 응용에 사용 가능하며, Protein A로 정제된 액상 형태입니다. 세포 신호전달 연구용으로 적합합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Bacterially expressed fusion protein representing amino acids 216–434 of human SLP76 with histidine tag |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1087319 |
Product Specific Information
This antibody reacts with SLP76, a 76 kDa cytosolic adaptor protein involved in signaling of various hematopoietic cells such as T cells, mast cells, and neutrophils. In B cells, it is replaced by SLP65.
Western Blot: Reducing conditions.
Target Information
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat.
The SLP-76 locus is located on human chromosome 5q33, and both human and murine cDNAs encode 533 amino acid proteins that are 72% identical.
The protein comprises three modular domains:
- NH2-terminus: acidic region with a PEST domain and tyrosine residues phosphorylated upon TCR ligation
- Central region: proline-rich domain
- COOH-terminus: SH2 domain
SLP-76 associates with multiple proteins both constitutively and inducibly following receptor ligation, functioning as an adaptor or scaffold protein.
Studies using SLP-76 deficient T cell lines or mice show its role in promoting T cell development, activation, mast cell, and platelet function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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