Thermo Fisher Scientific LIME Polyclonal Antibody
LIME 단백질의 세포질 도메인을 인식하는 Rabbit Polyclonal Antibody로, 인간 시료에 반응합니다. Western blot 및 IHC(Paraffin)에 사용 가능하며, Protein A로 정제된 액상 형태입니다. 4°C에서 보관하며, T세포 신호전달 연구용으로 적합합니다.
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Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Bacterially expressed intracellular fragment corresponding to aa 141–295 of human LIME |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1076494 |
Product Specific Information
This antibody reacts with the cytoplasmic domain of LIME, a 30 kDa Lck-interacting transmembrane adaptor expressed by T cells.
This antibody will not cross-react with mouse.
Target Information
LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with an unusually basic cytoplasmic domain, expressed by T cells.
After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and their negative regulator Csk.
Csk-mediated phosphorylation of the C-terminal negative-regulatory tyrosine of LIME-associated Lck can increase enzymatic activity compared with the total pool of Lck, thus LIME serves as a positive regulator of TCR-dependent T cell signaling.
However, under some circumstances, LIME may mediate inhibitory signals.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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