Thermo Fisher Scientific RbAp46 Polyclonal Antibody, Biotin

Applications

Tested Dilution

Publications

Western Blot (WB)

2 µg/mL

-

Immunohistochemistry (IHC)

Assay-dependent

-

Immunocytochemistry (ICC/IF)

Assay-dependent

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues M(1) A S K E M F E D T V E E(13) C of human RbAp46. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:RbAp46,uniProtId:Q16576-1,ncbiNodeId:9606,antigenRange:2-13,antigenLength:425,antigenImageFileName:PA1-1868_RbAp46_Q16576-1_Rabbit.svg,antigenImageFileNamePDP:PA1-1868_RbAp46_Q16576-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Biotin Biotin Biotin

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2539918

Product Specific Information

PA1.1-868 detects retinoblastoma protein (Rb) associated protein 46 from human cells.

PA1.1-868 has been successfully used in Western blot, ICC/IF and IHC applications. By Western blot, this antibody detects an ~46 kDa protein representing RbAp46 Biotin from HeLa cell lysate

The PA1.1-868 immunogen is a synthetic peptide corresponding to residues M(1) A S K E M F E D T V E E(13) C of human RbAp46. This sequence is completely conserved between human and mouse. PA1.1-868 immunizing peptide (Cat. # PEP-083) is available for use in neutralization and control experiments.

Target Information

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.