Thermo Fisher Scientific RbAp46 Polyclonal Antibody, Biotin
RbAp46 단백질을 검출하는 Biotin 결합 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 인간 및 마우스에서 보존된 서열 기반 면역원. 고농도(1 mg/mL) 액상 형태로 제공되며, -20°C 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 2 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: Assay-dependent
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues M(1) A S K E M F E D T V E E(13) C of human RbAp46 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2539918 |
Product Specific Information
PA1-1868 detects retinoblastoma protein (Rb) associated protein 46 from human cells.
It has been successfully used in Western blot, ICC/IF, and IHC applications.
By Western blot, this antibody detects an ~46 kDa protein representing RbAp46 Biotin from HeLa cell lysate.
The immunogen is a synthetic peptide corresponding to residues M(1) A S K E M F E D T V E E(13) C of human RbAp46.
This sequence is completely conserved between human and mouse.
The PA1-1868 immunizing peptide (Cat. # PEP-083) is available for use in neutralization and control experiments.
Target Information
RbAp46 is a ubiquitously expressed nuclear protein belonging to a highly conserved subfamily of WD-repeat proteins.
It binds directly to retinoblastoma protein, which regulates cell proliferation.
The encoded protein is found in several histone deacetylase complexes, including the mSin3 co-repressor complex, and participates in chromatin assembly.
It can interact with the BRCA1 tumor-suppressor gene and may play a role in regulating cell proliferation and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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