Thermo Fisher Scientific Nociceptin receptor Polyclonal Antibody
Nociceptin receptor를 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. WB, IHC, ICC, ELISA 등 다양한 응용에 적합하며, Protein A 정제 및 고순도 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific Nociceptin receptor Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from mouse Nociceptin receptor (amino acids 1–47) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The G-protein-coupled receptor (GPCR) superfamily includes approximately 600–1,000 members, representing the largest class of molecular targets with therapeutic relevance.
The nociceptin receptor is a G-protein coupled opioid receptor that binds the endogenous neuropeptide nociceptin. Ligand binding induces conformational changes that activate G protein signaling and modulate downstream effectors. This signaling inhibits adenylate cyclase and calcium channel activity. Arrestins regulate G protein signaling and activate MAP kinase pathways.
The receptor plays roles in nociception, pain perception, and regulation of locomotor activity by nociceptin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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