Thermo Fisher Scientific progesterone receptor Polyclonal Antibody

Thermo Fisher Scientific Progesterone Receptor Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy.
PR exists as a 94 kDa protein (Form A) and a 120 kDa protein (Form B) due to alternative translation initiation sites. PR-B is transcriptionally active and responsible for maintaining the endometrium, pregnancy, and inhibiting ovulation.
PR-A differs from PR-B by a 165 amino acid deletion at the N-terminus, exposing a 140 amino acid inhibitory domain that represses steroid hormone transcriptional activity.
In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins. Upon progesterone binding, the receptor undergoes conformational change, dimerizes, and binds to progesterone response elements (PRE) sequences to activate transcription.
A null mutation in the PGR gene leads to pleiotropic reproductive abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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