Thermo Fisher Scientific RON Monoclonal Antibody (K.811.10)
RON 단백질을 인식하는 Rabbit monoclonal antibody (Clone K.811.10). Western blot에 적합하며 인간 시료에 반응. MST1R/RON 수용체 연구에 유용. 비교적 높은 특이성과 안정성 제공. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:1,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | K.811.10 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Lys624 of human RON |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 15 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10983634 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other family members.
Target Information
MST1R (RON) is a receptor tyrosine kinase involved in cell proliferation and motility. It is a membrane-spanning, disulfide-linked heterodimer derived from a glycosylated precursor cleaved into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding induces tyrosine phosphorylation of the beta chain. Knockout studies show MST1R/RON (-/-) mice do not survive past the periimplantation period. The MST1R/RON gene is mapped to chromosome 3p21, a region frequently deleted or mutated in small cell lung and renal carcinoma, and is implicated in the progression of several epithelial cancers. Expression of MST1R/RON has been documented in many normal human tissues, including colon, mouth, prostate, and testis, as well as in various cancerous tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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