Thermo Fisher Scientific Btk Monoclonal Antibody (E.127.9)
BTK 단백질을 인식하는 토끼 단클론 항체로, Western blot 및 in vitro assay에 적합합니다. 인간 및 생쥐 시료에 반응하며, 높은 특이성과 재현성을 제공합니다. 액상 형태로 공급되며, -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- View 1 publication
In vitro Assay (IV)
- Tested Dilution: –
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | E.127.9 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Pro80 of human Btk |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 85 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10985666 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other unrelated proteins.
Target Information
Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily. Mutations in the BTK gene are linked to severe developmental blocks in human B-cell ontogeny and immunodeficiency disorders.
BTK interacts with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9, which play key roles in innate and adaptive immunity. It also interacts with proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting BTK’s involvement in lipopolysaccharide signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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